Normal Cone Function Requires the Interphotoreceptor Retinoid Binding Protein
نویسندگان
چکیده
منابع مشابه
Normal cone function requires the interphotoreceptor retinoid binding protein.
11-cis-retinal is the light-sensitive component in rod and cone photoreceptors, and its isomerization to all-trans retinal in the presence of light initiates the visual response. For photoreceptors to function normally, all-trans retinal must be converted back into 11-cis-retinal through a series of enzymatic steps known as the visual cycle. The interphotoreceptor retinoid-binding protein (IRBP...
متن کاملStructure-function relationships in interphotoreceptor retinoid-binding protein (IRBP).
PURPOSE Interphotoreceptor retinoid binding protein (IRBP) binds hydrophobic ligands in the retina. The polypeptide consists of 1230 amino acids in four 300 amino acid long repeats. We asked whether each of the four repeats can bind one retinoid or fatty acid analog. Our rationale was to make protein variants from the human cDNA bearing one or more of the repeats and examine binding capacities ...
متن کاملInterphotoreceptor Retinoid Binding Protein; Myths and Mysteries
Although it is the major soluble protein component of the extracellular matrix bathing the photoreceptors, little is known about the structure and function of interphotoreceptor retinoid-binding protein (IRBP). The critical anatomic compartment it occupies cannot be overemphasized as through the involution of the optic vesicle, the retinal pigmented epithelium (RPE) comes in contact with the ne...
متن کاملInterphotoreceptor retinoid-binding protein in the cone matrix sheath. Electron microscopic immunocytochemical localization.
Using a monoclonal antibody to chondroitin 6-sulfate, a major constituent of the cone matrix sheath, the location of the cone matrix sheath and the relative distribution of interphotoreceptor retinoid-binding protein (IRBP) was examined by light and electron microscopic immunocytochemistry. Chondroitin 6-sulfate immunoreactivity was localized to regions surrounding cone outer and inner segments...
متن کاملThe role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors.
The first event in light perception is absorption of a photon by the retinaldehyde chromophore of an opsin pigment in a rod or cone photoreceptor cell. This induces isomerization of the chromophore, rendering the bleached pigment insensitive to light. Restoration of light sensitivity requires chemical reisomerization of retinaldehyde via a multistep enzyme pathway, called the visual cycle, in c...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0063-09.2009